The Musculoskeletal Growth & Regeneration Laboratory (MGRL) received an R01 from the NIH/NIAMS to study muscle and bone comorbidities in Duchenne Muscular Dystrophy.
Project title: Targeting Nitrate-Nitrite-NO pathway for Ameliorating Muscle and Bone Comorbidities in Duchenne Muscular Dystrophy
Project period (5 years): 09/15/2020 to 08/31/2025
Total Award Amount: 1.7 million
This project is to evaluate the efficacy and study the mechanisms of action of oral nitrite administration as a novel therapeutic approach to replenish NO in dystrophic muscle by targeting the nitrate-nitrite-NO pathway, which is significantly disturbed in DMD. The unique beneficial effects of nitrite on both dystrophic skeletal muscle and bone tissues represents a novel intervention to treat dystrophic osteosacopenia in DMD.