Department of Orthopaedic Surgery

Jarrett D. Cain, DPM, MSc

  • Associate Professor

Education & Training

  • DPM, Temple University School of Podiatric Medicine, Philadelphia, PA
  • Residency: Virtua West Jersey Health System, Camden, NJ
  • Fellowship: Weil Foot and Ankle Institute, Des Plaines, IL
  • Master of Science, Drexel University College of Medicine, Philadelphia, PA

Representative Publications

  1. Cain JD, Dalmau Pastor M, Anatomy of Deltoid-Spring Ligament Complex, Foot & Ankle Clinics, 2021 26(2),
  2. Pirano JA, Theodoulou, MH, Ortiz J, Peterson K, Lundquist A, Hollawell S, Scott RT, Joseph R,  Mahan KT, Bresnahan PJ, Cain JD, Ford TC, Knight JM, Wobst GM, DPM. American College of Foot and Ankle Surgeons Clinical Consensus Statement: Appropriate Clinical Management of Adult-Acquired Flatfoot Deformity J Foot Ankle Surg. 2020 Mar - Apr; 59 (2):347-355. doi: 10.1053/j.jfas.2019.09.001
  3. Titunick MB, Lewis GS, Cain JD, Zagon IS, McLaughlin PJ. Blockade of the OGF-OGFr pathway in diabetic bone Connect Tissue Res. 2019 Nov;60(6):521-529. doi: 10.1080/03008207.2019.1593396
  4. Li F, Cain JD, Tombran-Tink J, Niyibizi C Pigment epithelium-derived factor (PEDF) reduced expression and synthesis of SOST/sclerostin in bone explant cultures: implication of PEDF-osteocyte gene regulation in vivo. J Bone Miner Metab. 2019 Sep;37(5):773-779. doi: 10.1007/s00774-018-0982-4
  5. Li F, Cain JD, Tombran-Tink J, Niyibizi C Pigment epithelium derived factor regulates human Sost/Sclerostin and other osteocyte gene expression via the receptor and induction of Erk/Gsk-3beta/beta-catenin signaling Biochim Biophys Acta Mol Basis Dis. 2018 Oct;1864(10):3449-3458. doi: 10.1016/j.bbadis.2018.07.034
  6. McLaughlin PJ, Cain JD, Titunick MB, Sassani JW and Zagon I.S.  Topical Naltrexone Is a Safe and Effective Alternative to Standard Treatment of Diabetic Wounds Advances in Wound Care,
  7. Patrick N, Lewis G, Roush E, Kunselman A, Cain JD.  Effects of Medial Displacement Calcaneal Osteotomy and Calcaneal Z Osteotomy on Subtalar Joint Pressures: A Cadaveric Flatfoot Model.   Journal of Foot and Ankle Surgery,
  8. Bahney, C. S., Bruder, S. P., Cain, JD, Keyak, J. H., Killian, M. L., Shapiro, I. M. and Jones, L. C. (2016), Accelerating the pace of discovery in orthopaedic research: A vision toward team science J Orthop Res 2016 Oct;34(10):1673-1679. doi: 10.1002/jor.23307

Research Interests

  • Foot & Ankle Disorders
  • Diabetic Bone Healing/Diabetic Limb Salvage
  • Flatfoot
  • Osteoarthritis
  • Hallux Valgus

Dr. Cain's research interests include disorders of the foot & ankle, diabetic bone healing, flatfoot deformity, and osteoarthritis. He has received various grants and has presented his research at various conferences nationally and internationally.  His research team was named a finalist for J. Leonard Goldner Award for best basic science research titled: Effect of Topical Opioid Antagonist on Diabetic Wound Healing in Rat Model.
Dr. Cain also serves on the Editorial Board of the Journal of Foot & Ankle Surgery.


Research Grants

Current Grant Support

  1. American Orthopaedic Foot and Ankle Society Research Grant Program 2021, Established Project Grants, Evaluation of frHMGB1 Treatment for Nonunion Fracture Healing in a Diabetic Rat Model, Principal Investigator (25%), $50,000 

  2. Drexel University-Wallace H. Coulter Translational Research Partnership Program, Orthopedic Surgical Devices with Controlled Fluid-Induced Expansion Properties for Improved Bone Fixation and Bone Integration, Co-Investigator, $80,000

Previous Grant Support

  1. Penn State Center for Orthopaedic Research and Translational Science Mini Pilot Grant 2018, Early Assessment of Diabetic Patients based on 2-Diminensional Radiographs, weight-bearing computer tomography and plantar pressure, Principal Investigator (75%), 2 years, $7,000
  1. American College of Foot and Ankle Surgeons Tri State Region Pilot Grant 2018. Evaluation of Proximal First Metatarsal Osteotomies with Weight-bearing Computed Tomography Imaging, Principal Investigator (75%), 2 years, $3,000
  1. Penn State College of Medicine Department of Neural and Behavioral Science 2016. Novel Naltrexone formulation for treatment of Diabetic foot ulcers, Co-Investigator (50%), 2 years, $25,000  
  1. Penn State College of Medicine Department of Neural and Behavioral Science 2016, Opioid Antagonist Treatment for Fracture Repair in Diabetic Rat Model, Co-Investigator (50%), 2 years, $25,000
  1. American College of Foot and Ankle Surgeons Research Grant 20154 Quantification of Altered Gait Mechanics and Energetics Following Partial Foot Amputation, Principal Investigator (50%), $15,000
  1. Penn State Orthopaedics Research Institute (Grant–917-85HY, 1940), Biomechanical analysis of calcaneal osteotomies, Principal Investigator (75%), 1 year, $5,000
  2. Penn State Orthopaedics Research Institute, Characterization of stem cell activity in Diabetic Bone Healing, Principal Investigator (75%), 3 years, $10,000