Department of Orthopaedic Surgery

Hongshuai Li, MD, PhD

  • Assistant Professor

Education & Training

  • MD, Shandong Medical University, Jinan, China
  • PhD, Shanghai Jiaotong University, Shanghai, China
  • Resident of Surgery, Shanghai Respiratory Hospital, Shanghai, China
  • Resident of Orthopaedics Surgery, Shanghai No.6 People’s Hospital, Shanghai, China
  • Post-Doc, Stem Cell Research Center, Department of Orthopaedics Surgery, University of Pittsburgh, PA

Representative Publications

  1. Li H*, Sun H, Qian B, Feng W, Carney D, Miller J, et al. Increased expression of FGF21 negatively affects bone homeostasis in dystrophin/utrophin double knock-out mice. Journal of Bone and Mineral Research, 2019, PMID: 31800971. (*Corresponding author)
  2. Sherrier M, Li H*. The impact of keto-adaptation on exercise performance and the role of metabolic-regulating cytokines. The American Journal of Clinical Nutrition, 2019, PMID: 31347659. (*Corresponding author)
  3. Zhou S, Qian B, Wang L, Zhang C, Hogan M, Li H*. Altered bone-regulating myokine expression in skeletal muscle of Duchenne muscular dystrophy mouse models. Muscle & Nerve, 2018, PMID: 30028902. (*Corresponding author)
  4. Wright VJ, McCrum CL, Li H, Tranovich MJ, Huard J. Significant chondrocyte viability is present in acetabular chondral flaps associated with femoroacetabular impingement. The American Journal of Sports Medicine, 2017, PMID: 29024597.
  5. Li H*, Lu A, Tang Y, Beckman S, Nakayama N, Poddar M, Hogan, M, Huard, J*. The superior regenerative potential of muscle derived stem cells for articular cartilage repair is attributed to high cell survival and chondrogenic potential. Molecular Therapy - Methods & Clinical Development, 2016, 3: 16065. PMID: 27990446. (*Corresponding author)
  6. Li H*, Hicks J, Wang L, Oyster N, Philippon M, Hurwitz S, Hogan M, Huard J*. Customized platelet-rich plasma with transforming growth factor beta-1 neutralization antibody to reduce fibrosis in skeletal muscle. Biomaterials, 2016, 87: 147-156. PMID: 26923362 (*Corresponding author)
  7. Li H, Johnson N, Usas A, Lu A, Wang Y, Huard J. Sustained release of BMP2 via coacervate improves the osteogenic potential of muscle derived stem cells. Stem Cells Translational Medicine, 2013, 2 (9):667-77. PMID: 23884640 
  8. Li H, Usas A, Chen W, Poddar M, Huard J. Platelet-rich plasma promotes the proliferation of human muscle derived progenitor cells and maintains their stemness. PLoS ONE, 2013, 8(6):e64923. PMID: 23762264
  9. Li H, Li B. PRP as a New Approach to Prevent Infection: Preparation and in vitro Antimicrobial Properties of PRP. Journal of Visualized Experiments, 2013, e50351, doi:10.3791/50351. PMID: 23609458
  10. Li H, Hamza T, Tidwell J, Clovis N, and Li B. Unique antimicrobial effects of platelet-rich plasma and its efficacy as a prophylaxis to prevent implant-associated spinal infection. Advanced Healthcare Materials, 2013, 2 (9):1277-84. PMID: 23447088

    Pubmed link

    Research Interests

    • To understand how skeletal muscle, the largest organ in the body, communicates with other organs as a harbor of progenitor cells and signaling molecules.
    • To develop therapies targeting skeletal muscle to treat various musculoskeletal injuries and degenerative conditions.

    Research Grants

    Ongoing Research:

    1. Pathological role of muscle-derived FGF21 on bone metabolism in Duchenne Muscular Dystrophy
    Project period: 07/01/2019-06/30/2021
    Sponsor: Competitive Medical Research Fund of the UMPC Health System
    Role: Principal Investigator

    2. Role of muscle-derived FGF21 in bone abnormalities in Duchenne Muscular Dystrophy
    Project Period:  07/01/2019-06/30/2020
    Sponsor:  Albert B. Ferguson, Jr, MD Orthopaedic Fund of the Pittsburgh Foundation
    Role: Principal Investigator

    3. Impact of Leukemia Inhibitory Factor on Bone Health in Duchenne Muscular Dystrophy
    Project Period:  03/01/2020-03/01/2021
    Sponsor:  Osteoporosis-related Rehabilitation Research Grant Research Grant-Foundation for Physical Medicine and Rehabilitation
    Role: Co-Investigator (Mentor)

    Completed Research:

     

    1.  Explore pathogenesis of bone abnormalities in Duchenne Muscular Dystrophy
    Project Period:  07/01/2018-06/30/2019
    Sponsor:  Samuel and Emma Winters Foundation
    Role: Principal Investigator.

    2. Nitrite as a novel therapeutic strategy to replenish muscle nitrite oxide for the treatment of Duchenne Muscular Dystrophy
    Project period: 07/01/2016-06/30/2017
    Sponsor: Albert B. Ferguson, Jr, MD Orthopaedic Fund of the Pittsburgh Foundation
    Award type: AD2016-1765-29   
    Role: Principal Investigator

    3. Bone Abnormalities & Healing Defect in Muscular Dystrophy
    Project period: 05/06/2014-04/30/2019
    Sponsor: NIH
    Award type: R01-1R01AR065445-01
    Role: Co-Investigator

    4. The Use of Coavervate Technology as a New Drug Delivery System for Musculoskeletal Tissue Repair
    Project period: 04/04/2014-03/31/2016
    Sponsor: NIH
    Award type: R21-5R21AR066206-02
    Role: Co-Investigator