Department of Orthopaedic Surgery

Department to Collaborate On $16.8M NIH Study Aimed at Transforming Children's Surgical Pain Management

We are excited to announce that members of our orthopaedic care family at UPMC Children's will be collaborating on an important NIH study aimed at transforming pain management for children undergoing major surgeries. Departmental investigators will work with various departments across the University, including Dr. Ozgur Dede, Chief, Division of Pediatric Orthopaedic Surgery. 

The project, titled “Implementing and Personalizing Best-In-Class Opioid-Sparing Pain Management for Major Inpatient Surgeries in Children,” aims to conduct multicenter PRECISE Analgesia trials. These trials will focus on implementing and investigating the efficacy and safety of a multidose methadone-based standardized Enhanced Recovery After Surgery (ERAS) protocol, along with developing personalized ERAS protocols for safe, effective opioid-sparing pain management following major surgeries such as posterior spine fusion (PSF) and cardiac surgery (CS) in children.

Click here for more information about the study and the grant.